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Congenital Zika syndrome is associated with maternal protein malnutrition

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dc.contributor.author Barbeito-Andrés, J.
dc.contributor.author Pezzuto, P.
dc.contributor.author Higa, L. M.
dc.contributor.author Dias, A. A.
dc.contributor.author Vasconcelos, J. M.
dc.contributor.author Santos, T. M. P.
dc.contributor.author Ferreira, J. C. C. G.
dc.contributor.author Ferreira, R. O.
dc.contributor.author Dutra, F. F.
dc.contributor.author Rossi, A. D.
dc.contributor.author Barbosa, R. V.
dc.contributor.author Amorim, C. K. N.
dc.contributor.author De Souza, M. P. C.
dc.contributor.author Chimelli, L.
dc.contributor.author Aguiar, R. S.
dc.contributor.author Gonzalez, P. N.
dc.contributor.author Lara, F. A.
dc.contributor.author Castro, M. C.
dc.contributor.author Molnár, Z.
dc.contributor.author Lopes, R. T.
dc.contributor.author Bozza, M. T.
dc.contributor.author Vianez, J. L. S. G.
dc.contributor.author Barbeito, C. G.
dc.contributor.author Cuervo, P.
dc.contributor.author Bellio, M.
dc.contributor.author Tanuri, A.
dc.contributor.author Garcez, P. P.
dc.date.accessioned 2023-04-11T17:35:19Z
dc.date.available 2023-04-11T17:35:19Z
dc.date.issued 2020-06-10
dc.identifier.other DOI: 10.1126/sciadv.aaw6284
dc.identifier.uri http://repositorio.hospitalelcruce.org/xmlui/handle/123456789/1357
dc.description Fil: Barbeito-Andrés, J. Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Pezzuto, P. Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil. es
dc.description Fil: Higa, L. M. Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Dias, A. A. Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Vasconcelos, J. M. Biological Science Institute, Federal University of Pará. Belém; Brazil. es
dc.description Fil: Santos, T. M. P. Nuclear Instrumentation Laboratory, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Ferreira, J. C. C. G. Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Ferreira, R. O. Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Dutra, F. F. Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Rossi, A. D. Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Barbosa, R. V. CENABIO (National Center of Structural Biology and Bioimaging). Rio de Janeiro; Brazil es
dc.description Fil: Amorim, C. K. N. Technological Innovations Centre, Evandro Chagas Institute. Ananindeua; Brazil es
dc.description Fil: De Souza, M. P. C. Technological Innovations Centre, Evandro Chagas Institute. Ananindeua; Brazil es
dc.description Fil: Chimelli, L. State Institute of Brain Paulo Niemeyer. Rio de Janeiro; Brazil es
dc.description Fil: Aguiar, R. S. Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Gonzalez, P. N. Institute for Studies in Neuroscience and Complex Systems (ENyS) CONICET. Buenos Aires; Argentina es
dc.description Fil: Lara, F. A. Oswaldo Cruz Institute, Fiocruz. Rio de Janeiro; Brazil es
dc.description Fil: Castro, M. C. Department of Global Health and Population, Harvard T. H. Chan School of Public Health. Boston, MA; USA. es
dc.description Fil: Molnár, Z. Department of Physiology, Anatomy and Genetics, University of Oxford. Oxford; UK es
dc.description Fil: Lopes, R. T. Nuclear Instrumentation Laboratory, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Bozza, M. T. Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil. es
dc.description Fil: Vianez, J. L. S. G. Technological Innovations Centre, Evandro Chagas Institute. Ananindeua; Brazil es
dc.description Fil: Barbeito, C. G. Faculty of Veterinary Sciences, National University of La Plata. Buenos Aires; Argentina es
dc.description Fil: Cuervo, P. Oswaldo Cruz Institute, Fiocruz. Rio de Janeiro; Brazil es
dc.description Fil: Bellio, M. Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Tanuri, A. Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description Fil: Garcez, P. P. Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Rio de Janeiro; Brazil es
dc.description.abstract Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS. es_AR
dc.language.iso en es_AR
dc.subject Virus, Zika es_AR
dc.subject ZikV es_AR
dc.subject Malnutrition, Severe Acute es_AR
dc.title Congenital Zika syndrome is associated with maternal protein malnutrition es_AR
dc.type Article es_AR


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