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Lidocaine protects neurons of the spinal cord in an excitotoxicity model

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dc.contributor.author Sisti, María S.
dc.contributor.author Nishida, Fabián
dc.contributor.author Zanuzzi, Carolina N.
dc.contributor.author Laurella, Sergio L.
dc.contributor.author Cantet, Rodolfo J.C.
dc.contributor.author Portiansky, Enrique L.
dc.date.accessioned 2023-04-18T18:49:58Z
dc.date.available 2023-04-18T18:49:58Z
dc.date.issued 2019-01-08
dc.identifier.citation Sisti MS, Nishida F, Zanuzzi CN, Laurella SL, Cantet RJC, Portiansky EL, Lidocaine protects neurons of the spinal cord in an excitotoxicity model, Neuroscience Letters (2019), https://doi.org/10.1016/j.neulet.2019.01.019 es_AR
dc.identifier.other https://doi.org/10.1016/j.neulet.2019.01.019
dc.identifier.uri http://repositorio.hospitalelcruce.org/xmlui/handle/123456789/1361
dc.description Fil: Sisti, María S. Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata (UNLP), 60 y 118, s/n, La Plata. Buenos Aires; Argentina es
dc.description Fil: Nishida, Fabián Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata (UNLP), 60 y 118, s/n, La Plata. Buenos Aires; Argentina es
dc.description Fil: Zanuzzi, Carolina N. Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata (UNLP), 60 y 118, s/n, La Plata. Buenos Aires; Argentina es
dc.description Fil: Laurella, Sergio L. CEDECOR, Department of Chemistry, School of Exact Sciences, Universidad Nacional de La Plata, 47 y 115, s/n, La Plata. Buenos Aires; Argentina es
dc.description Fil: Cantet, Rodolfo J.C. National Research Council of Science and Technology (CONICET). Buenos Aires; Argentina es
dc.description Fil: Portiansky, Enrique L. Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata (UNLP), 60 y 118, s/n, La Plata. Buenos Aires; Argentina. es
dc.description.abstract Motor Neuron Disease disorders, described in domestic animals, are characterized by neuronal degeneration at the spinal cord. Excitotoxicity is a crucial factor for the selective loss of these neurons, being the fundamental processes involved in lesion progression after spinal cord injury, where glutamate is one of the main neurotransmitters involved. Kainic acid (KA) resembles the effects induced by the pathological release of glutamate. Lidocaine administered by different routes exerts some neuroprotective effects in the CNS. The aim of the present work was to determine whether lidocaine simultaneously injected with KA into the spinal cord could prevent the excitotoxic effects of the latter. Sprague-Dawley rats were injected by intraparenchymal route with KA or with KA plus 0.5% lidocaine into the C5 segment. Sham rats were injected with saline. Animals were motor and sensory tested at 0, 1, 2, 3, 7 and 14 post-injection days and then euthanized. Sections of the C5 segment were used for histological and immunohistochemical analysis. No KA-induced motor and sensitive impairments were observed when lidocaine was simultaneously injected with KA. Moreover, neuronal counting was statistically higher when compared with KA-injected animals. Thus, lidocaine could be considered as a neuroprotective drug in diseases and models involving excitotoxicity. es_AR
dc.language.iso en es_AR
dc.relation.ispartofseries Neuroscience Letters;vol. 698 p. 105 - 112
dc.subject Excitotoxicity es_AR
dc.subject Kainic acid es_AR
dc.subject Neuroprotection es_AR
dc.subject Lidocaine es_AR
dc.title Lidocaine protects neurons of the spinal cord in an excitotoxicity model es_AR
dc.type Article es_AR


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