Mostrar el registro sencillo del ítem
dc.contributor.author | Andrés, Jimena Barbeito | |
dc.contributor.author | Fonseca, Emily Castro | |
dc.contributor.author | Qiu, Lily R. | |
dc.contributor.author | Bernal, Valeria | |
dc.contributor.author | Lent, Roberto | |
dc.contributor.author | Henkelman, Mark | |
dc.contributor.author | Lukowiak, Kenneth | |
dc.contributor.author | Gleiser, Pablo M. | |
dc.contributor.author | Hallgrimsson, Benedikt | |
dc.contributor.author | Gonzalez, Paula N. | |
dc.date.accessioned | 2023-04-20T18:06:54Z | |
dc.date.available | 2023-04-20T18:06:54Z | |
dc.date.issued | 2019-09-05 | |
dc.identifier.citation | y The Company of Biologists Ltd | Journal of Experimental Biology (2019) 222, jeb204651. doi:10.1242/jeb.204651 | es_AR |
dc.identifier.other | doi:10.1242/jeb.204651 | |
dc.identifier.uri | http://repositorio.hospitalelcruce.org/xmlui/handle/123456789/1362 | |
dc.description | Fil: Andrés, Jimena Barbeito Institute for Studies in Neuroscience and Complex Systems Studies, ENyS, CONICET, CP 1888. Buenos Aires; Argentina | es |
dc.description | Fil: Fonseca, Emily Castro Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Rio de Janeiro, 21941-590; Brazil. | es |
dc.description | Fil: Qiu, Lily R. Mouse Imaging Centre, Hospital for Sick Children. Toronto, ON M5T 3H7; Canada | es |
dc.description | Fil: Bernal, Valeria Anthropology Department, School of Natural Sciences, National University of La Plata. C1925 Buenos Aires; Argentina | es |
dc.description | Fil: Lent, Roberto Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Rio de Janeiro, 21941-590; Brazil | es |
dc.description | Fil: Henkelman, Mark Mouse Imaging Centre, Hospital for Sick Children. Toronto, ON M5T 3H7; Canada | es |
dc.description | Fil: Lukowiak, Kenneth Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary. Calgary, AB T2N 4N1; Canada | es |
dc.description | Fil: Gleiser, Pablo M. Medical Physics Department, Bariloche Atomic Centre, Bariloche. Rio Negro; Argentina | es |
dc.description | Fil: Hallgrimsson, Benedikt Department of Cell Biology and Anatomy, McCaig Institute for Bone and Joint Health, Alberta Children’s Hospital Research Institute, University of Calgary. Calgary, AB T2N 1N4; Canada | es |
dc.description | Fil: Gonzalez, Paula N. Institute for Studies in Neuroscience and Complex Systems Studies, ENyS, CONICET. CP 1888 Buenos Aires; Argentina | es |
dc.description.abstract | Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition. | es_AR |
dc.language.iso | en | es_AR |
dc.relation.ispartofseries | Journal of Experimental Biology;222 | |
dc.subject | Olfactory Cortex | es_AR |
dc.subject | Cerebellums | es_AR |
dc.subject | Elasticity Imaging Techniques | es_AR |
dc.title | Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction | es_AR |
dc.type | Article | es_AR |