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Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction

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dc.contributor.author Andrés, Jimena Barbeito
dc.contributor.author Fonseca, Emily Castro
dc.contributor.author Qiu, Lily R.
dc.contributor.author Bernal, Valeria
dc.contributor.author Lent, Roberto
dc.contributor.author Henkelman, Mark
dc.contributor.author Lukowiak, Kenneth
dc.contributor.author Gleiser, Pablo M.
dc.contributor.author Hallgrimsson, Benedikt
dc.contributor.author Gonzalez, Paula N.
dc.date.accessioned 2023-04-20T18:06:54Z
dc.date.available 2023-04-20T18:06:54Z
dc.date.issued 2019-09-05
dc.identifier.citation y The Company of Biologists Ltd | Journal of Experimental Biology (2019) 222, jeb204651. doi:10.1242/jeb.204651 es_AR
dc.identifier.other doi:10.1242/jeb.204651
dc.identifier.uri http://repositorio.hospitalelcruce.org/xmlui/handle/123456789/1362
dc.description Fil: Andrés, Jimena Barbeito Institute for Studies in Neuroscience and Complex Systems Studies, ENyS, CONICET, CP 1888. Buenos Aires; Argentina es
dc.description Fil: Fonseca, Emily Castro Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Rio de Janeiro, 21941-590; Brazil. es
dc.description Fil: Qiu, Lily R. Mouse Imaging Centre, Hospital for Sick Children. Toronto, ON M5T 3H7; Canada es
dc.description Fil: Bernal, Valeria Anthropology Department, School of Natural Sciences, National University of La Plata. C1925 Buenos Aires; Argentina es
dc.description Fil: Lent, Roberto Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Rio de Janeiro, 21941-590; Brazil es
dc.description Fil: Henkelman, Mark Mouse Imaging Centre, Hospital for Sick Children. Toronto, ON M5T 3H7; Canada es
dc.description Fil: Lukowiak, Kenneth Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary. Calgary, AB T2N 4N1; Canada es
dc.description Fil: Gleiser, Pablo M. Medical Physics Department, Bariloche Atomic Centre, Bariloche. Rio Negro; Argentina es
dc.description Fil: Hallgrimsson, Benedikt Department of Cell Biology and Anatomy, McCaig Institute for Bone and Joint Health, Alberta Children’s Hospital Research Institute, University of Calgary. Calgary, AB T2N 1N4; Canada es
dc.description Fil: Gonzalez, Paula N. Institute for Studies in Neuroscience and Complex Systems Studies, ENyS, CONICET. CP 1888 Buenos Aires; Argentina es
dc.description.abstract Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition. es_AR
dc.language.iso en es_AR
dc.relation.ispartofseries Journal of Experimental Biology;222
dc.subject Olfactory Cortex es_AR
dc.subject Cerebellums es_AR
dc.subject Elasticity Imaging Techniques es_AR
dc.title Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction es_AR
dc.type Article es_AR


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