Resumen:
Epilepsy surgery depends on accurate preoperative localization of the epileptogenic zone (EZ). Then, presurgical evaluation is necessary to obtain the most accurate information from clinical, anatomic, and neurophysiologic aspects, with the final goal of performing a personalized surgical treatment. The noninvasive methods of seizure localization and their results must be interpreted in conjunction, to achieve establish localization hypotheses of the anatomic location of the EZ. This chapter presents evidence supporting that Stereoelectroencephalography is an extraoperative invasive method useful to anatomically define the EZ and the related functional cortical areas of patients with medically refractory focal epilepsy.