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Hepatitis C virus diversification in Argentina: comparative analysis between the Large City of Buenos Aires and the small rural town of O'Brien

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dc.contributor.author Golemba, Marcelo
dc.contributor.author Culasso, Andrés
dc.contributor.author Villamil, Federico
dc.contributor.author Bare, Patricia
dc.contributor.author Gadano, Adrián
dc.contributor.author Ridruejo, Ezequiel
dc.contributor.author Martinez, Alfredo
dc.contributor.author Di Lello, Federico
dc.contributor.author Campos, Rodolfo
dc.date.accessioned 2016-01-26T17:09:31Z
dc.date.available 2016-01-26T17:09:31Z
dc.date.issued 2013
dc.identifier.citation Golemba MD, Culasso ACA, Villamil FG, Bare P, Gadano A, Ridruejo E, et al. (2013) Hepatitis C Virus Diversification in Argentina: Comparative Analysis between the Large City of Buenos Aires and the Small Rural Town of O'Brien. PLoS ONE 8(12): e84007. doi:10.1371/journal.pone.0084007 es_AR
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/123456789/200
dc.description Fil: Villamil, F. Hospital de Alta Complejidad en Red El Cruce Dr. Néstor C. Kirchner. Unidad de Trasplante Hepático. Florencio Varela, Argentina. es_AR
dc.description.abstract Background The estimated prevalence of HCV infection in Argentina is around 2%. However, higher rates of infection have been described in population studies of small urban and rural communities. The aim of this work was to compare the origin and diversification of HCV-1b in samples from two different epidemiological scenarios: Buenos Aires, a large cosmopolitan city, and O'Brien, a small rural town with a high prevalence of HCV infection. Patients and Methods The E1/E2 and NS5B regions of the viral genome from 83 patients infected with HCV-1b were sequenced. Phylogenetic analysis and Bayesian Coalescent methods were used to study the origin and diversification of HCV-1b in both patient populations. Results Samples from Buenos Aires showed a polyphyletic behavior with a tMRCA around 1887–1900 and a time of spread of infection approximately 60 years ago. In contrast, samples from ÓBrien showed a monophyletic behavior with a tMRCA around 1950–1960 and a time of spread of infection more recent than in Buenos Aires, around 20–30 years ago. Conclusion Phylogenetic and coalescence analysis revealed a different behavior in the epidemiological histories of Buenos Aires and ÓBrien. HCV infection in Buenos Aires shows a polyphyletic behavior and an exponential growth in two phases, whereas that in O'Brien shows a monophyletic cluster and an exponential growth in one single step with a more recent tMRCA. The polyphyletic origin and the probability of encountering susceptible individuals in a large cosmopolitan city like Buenos Aires are in agreement with a longer period of expansion. In contrast, in less populated areas such as O'Brien, the chances of HCV transmission are strongly restricted. Furthermore, the monophyletic character and the most recent time of emergence suggest that different HCV-1b ancestors (variants) that were in expansion in Buenos Aires had the opportunity to colonize and expand in O’Brien es_AR
dc.language.iso en_US es_AR
dc.publisher Public Library of Science (PLOS) es_AR
dc.subject Hepatitis C es_AR
dc.subject Análisis Demográfico es_AR
dc.subject Argentina es_AR
dc.subject Dinámica de Población es_AR
dc.title Hepatitis C virus diversification in Argentina: comparative analysis between the Large City of Buenos Aires and the small rural town of O'Brien es_AR
dc.type Article es_AR


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