Repositorio Digital

Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors

Mostrar el registro sencillo del ítem Geoghegan, Sarah Erviti, Anabella ES Caballero, Mauricio T ES Vallone, Fernando ES Zanone, Stella M ES Losada, Juan Ves ES Bianchi, Alejandra ES Acosta, Patricio L ES Talarico, Laura B ES Ferretti, Adrian ES Grimaldi, Luciano Alva ES Sancilio, Andrea ES Duenas, Karina ES Sastre, Gustavo ES Rodriguez, Andrea ES Ferrero, Fernando ES Barboza, Edgar ES Gago, Guadalupe Fernandez ES Nocito, Celina ES Flamenco, Edgardo ES Perez, Alberto Rodriguez ES Rebec, Beatriz ES Ferolla, F Martin ES Libster, Romina ES Karron, Ruth A ES Bergel, Eduardo ES Polack, Fernando P ES 2018-01-23T18:17:47Z 2018-01-23T18:17:47Z 2017
dc.identifier.citation Am J Respir Crit Care Med. 2017 Jan 1;195(1):96-103. doi: 10.1164/rccm.201603-0658OC. es_AR
dc.identifier.issn 1535-4970
dc.description Fil: Ves Losada, J. Hospital de Alta Complejidad en Red El Cruce Dr. Néstor C. Kirchner. Servicio de Pediatría. Florencio Varela, Argentina. es_AR
dc.description Fil: Erviti, A. Fundacion INFANT, Buenos Aires, Argentina. ES
dc.description Fil: Caballero, MT. Fundacion INFANT, Buenos Aires, Argentina. ES
dc.description.abstract Rationale: Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is unclear. Objectives: To determine the burden and risk factors for mortality due to RSV in a low-income population of 84,840 infants. Methods: This was a prospective, population-based, cross-sectional, multicenter study conducted between 2011 and 2013. Hospitalizations and deaths due to severe lower respiratory tract illness (LRTI) were recorded during the RSV season. All-cause hospital deaths and community deaths were monitored. Risk factors for respiratory failure (RF) and mortality due to RSV were assessed using a hierarchical, logistic regression model. Measurements and Main Results: A total of 2,588 (65.5%) infants with severe LRTI were infected with RSV. A total of 157 infants (148 postneonatal) experienced RF or died with RSV. RSV LRTI accounted for 57% fatal LRTI tested for the virus. A diagnosis of sepsis (odds ratio [OR], 17.03; 95% confidence interval [CI], 13.14–21.16 for RF) (OR, 119.39; 95% CI, 50.98–273.34 for death) and pneumothorax (OR, 17.15; 95% CI, 13.07–21.01 for RF) (OR, 65.49; 95% CI, 28.90–139.17 for death) were the main determinants of poor outcomes. Conclusions: RSV was the most frequent cause of mortality in low-income postneonatal infants. RF and death due to RSV LRTI, almost exclusively associated with prematurity and cardiopulmonary diseases in industrialized countries, primarily affect term infants in a developing world environment. Poor outcomes at hospitals are frequent and associated with the cooccurrence of bacterial sepsis and clinically significant pneumothoraxes. es_AR
dc.language.iso en es_AR
dc.subject Cost of Illness es_AR
dc.subject Costo de Enfermedad es_AR
dc.subject Cross-Sectional Studies es_AR
dc.subject Estudios Transversales es_AR
dc.subject Hospitalización es_AR
dc.subject Hospitalization es_AR
dc.subject Modelos Logísticos es_AR
dc.subject Logistic Models es_AR
dc.subject Lactante es_AR
dc.subject Infant es_AR
dc.subject Pneumothorax es_AR
dc.subject Neumotórax es_AR
dc.subject Infecciones por Virus Sincitial Respiratorio es_AR
dc.subject Respiratory Syncytial Virus Infections es_AR
dc.title Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors es_AR
dc.type Article es_AR

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