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Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model

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dc.contributor.author Correger, Enrique
dc.contributor.author Marcos, Josefina
dc.contributor.author Laguens, Graciela
dc.contributor.author Stringa, Pablo
dc.contributor.author Cardinal-Fernández, Pablo
dc.contributor.author Blanch, Lluis
dc.date.accessioned 2020-04-23T16:34:07Z
dc.date.available 2020-04-23T16:34:07Z
dc.date.issued 2020-04
dc.identifier.issn 1982-4335
dc.identifier.uri http://rbti.org.br/artigo/detalhes/0103507X-32-1-10
dc.identifier.uri http://repositorio.hospitalelcruce.org/xmlui/handle/123456789/956
dc.description Fil: Correger, E. Hospital de Alta Complejidad en Red El Cruce Dr. Néstor C. Kirchner. Unidad de Cuidados Intensivos. Florencio Varela, Argentina. es_AR
dc.description.abstract OBJECTIVE: To determine whether adalimumab administration before mechanical ventilation reduces ventilator-induced lung injury (VILI). METHODS: Eighteen rats randomized into 3 groups underwent mechanical ventilation for 3 hours with a fraction of inspired oxygen = 0.40% including a low tidal volume group (n = 6), where tidal volume = 8mL/kg and positive end-expiratory pressure = 5cmH2O; a high tidal volume group (n = 6), where tidal volume = 35mL/kg and positive end-expiratory pressure = 0; and a pretreated + high tidal volume group (n = 6) where adalimumab (100ug/kg) was administered intraperitoneally 24 hours before mechanical ventilation + tidal volume = 35mL/kg and positive end-expiratory pressure = 0. ANOVA was used to compare histological damage (ATS 2010 Lung Injury Scoring System), pulmonary edema, lung compliance, arterial partial pressure of oxygen, and mean arterial pressure among the groups. RESULTS: After 3 hours of ventilation, the mean histological lung injury score was higher in the high tidal volume group than in the low tidal volume group (0.030 versus 0.0051, respectively, p = 0.003). The high tidal volume group showed diminished lung compliance at 3 hours (p = 0.04) and hypoxemia (p = 0,018 versus control). Pretreated HVt group had an improved histological score, mainly due to a significant reduction in leukocyte infiltration (p = 0.003). CONCLUSION: Histological examination after 3 hours of injurious ventilation revealed ventilator-induced lung injury in the absence of measurable changes in lung mechanics or oxygenation; administering adalimumab before mechanical ventilation reduced lung edema and histological damage. es_AR
dc.language.iso es es_AR
dc.publisher Associação de Medicina Intensiva Brasileira - AMIB es_AR
dc.relation.ispartofseries Rev Bras Ter Intensiva;2020;32(1):58-65
dc.subject Adalimumab es_AR
dc.subject Respiración Artificial es_AR
dc.subject Ventiladores Mecánicos es_AR
dc.title Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model es_AR
dc.type Article es_AR


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