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Vitamin D supplementation as a rational pharmacological approach 3 in the COVID-19 pandemic

Mostrar el registro sencillo del ítem Ferder, León Martín Giménez, Virna Margarita Inserra, Felipe Tajer, Carlos Antonietti, Laura Mariani, Javier Manucha, Walter 2020-10-07T15:56:54Z 2020-10-07T15:56:54Z 2020-09-30
dc.description Fil: Ferder, León. University of Miami; Miami; Estados Unidos es_AR
dc.description.abstract The COVID-19 pandemic has reached most of the countries worldwide causing death, which often results from an inflammatory storm associated with severe acute respiratory syndrome (SARS). This has prompted researchers to seek specific novel and definitive treatments urgently. In this context, it is interesting to evaluate the preventive and therapeutic effects of existing pharmacological agents that could be useful. In this regard, vitamin D supplementation, particularly in individuals likely to be deficient, may be a promising option. Vitamin D is a hormone that modulates many of the same inflammatory and oxidative signaling pathways triggered during COVID-19. For example, vitamin D suppresses the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response related to COVID-19. This paper analyzes the evidence that vitamin D supplementation might be a valuable preventive/therapeutic measure in groups at risk of or infected with COVID-19. It also discusses how clinical studies could be best designed to evaluate the possible advantages of vitamin D supplementation for the benefit of public health during the pandemic. es_AR
dc.language.iso es es_AR
dc.relation.ispartofseries Am J Physiol Lung Cell Mol Physiol;2020 Sep 30
dc.subject Infecciones por Coronavirus es_AR
dc.subject Vitamina D es_AR
dc.title Vitamin D supplementation as a rational pharmacological approach 3 in the COVID-19 pandemic es_AR
dc.type Article es_AR

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