Centro de Medicina Traslacional (CEMET): Envíos recientes

  • Comprehensive approach for the genetic diagnosis of patients with waardenburg syndrome 
    Buonfiglio, Paula Inés; Izquierdo, Agustín; Pace, Mariela Vanina; Grinberg, Sofía; Lotersztein, Vanesa; Brun, Paloma; Bruque, Carlos David; Elgoyhen, Ana Belén; Dalamón, Viviana (2024-08-27)
    [ABSTRACT]. Abstract: Waardenburg syndrome (WS) is a common genetic cause of syndromic hearing loss, accounting for 2–5% of congenital cases. It is characterized by hearing impairment and pigmentation abnormalities in ...
  • Overcoming limited access to virus infection rapid testing: development of a lateral flow test for SARS-Cov-2 with locally available resources 
    Ibáñez, Estefanía S. Peri; Mazzeo, Agostina; Silva, Carolina; Juncos, Maria Juliana; Navarro, Guadalupe S. Costa; Pallarés, Horacio; Wolos, Virginia; Fiszman, Gabriel; Mundo, Silvia; Caramelo, Julio; Yanovsky, Marcelo; Fingermann, Matías; Castello, Alejandro; Gamarnik, Andrea; Peinetti, Ana; Capdevila, Daiana (2024-08-27)
    [ABSTRACT]. The COVID-19 pandemic highlighted testing inequities in developing countries. Lack of lateral flow test (LFT) manufacturing capacity was a major COVID-19 response bottleneck in low- and middle-income regions. ...
  • Flow cytometry "Ogata score" for the diagnosis of myelodysplastic syndromes in a real-life setting. A Latin American experience 
    Grille Montauban, Sofía; Hernandez-Perez, Carlos; Velloso, Elvira; Novoa, Viviana; Lorand-Metze, Irene; Gonzalez, Jaqueline; Solari, Liliana; Cismondi, Valeria; Serrano, Juan Carlos; Burgnini, Andreína; Rabelo-Carrasco, Laura; Bacal, Nydia; Trias, Natalia; Guevara, Romina; Rico Vido, Joyce; Crisp, Renee; Enrico, Alicia; Boada, Matilde; Pereira Cunha, Fernanda; Fanessi, Viviana; Venegas, María Belén; Issouribehere, Diego; Novoa, Andrea; Lens, Daniela (2019-08-05)
    INTRODUCTION: Flow cytometry (FC) is a helpful tool for the diagnosis of myelodysplastic syndrome (MDS). Different FC score systems have been developed. The "Ogata score" is a simple diagnostic score that ...
  • Diferencias semiológicas entre crisis del lóbulo frontal y crisis funcionales 
    Daza, Restrepo A.; Matus, Mayorga R.; Pino, S.; Oddo, S.; Nasimbera, A.; Campora, N.; Kochen, S.; Giagante, B. (2023-11-07)
    Las crisis funcionales (CF) se asemejan a crisis epilépticas (CE) pero no tienen correlato epileptiforme en el electroencefalograma (EEG), representando un desafío en el abordaje médico. El principal diagnóstico diferencial ...
  • Mechanical Power Correlates With Stress, Strain, and Atelectrauma Only When Normalized to Aerated Lung Size in Patients With Acute Respiratory Distress Syndrome 
    Pistillo, Néstor; Castelluccio, Pablo; Suzuki, Ichiro; Castiblanco, Lina (2023-09-22)
    OBJECTIVES: First, to investigate whether the severity of acute respiratory distress syndrome (ARDS) influences ventilator-induced lung injury (VILI) risk in ventilated patients with similar mechanical power of respiratory ...
  • Consciousness transitions during epilepsy seizures through the lens of Integrated Information Theory 
    Baglivo, Fabricio; Campora, Nuria; Mininni, Camilo; Kochen, Silvia; Lew, Sergio (2023-10-30)
    Consciousness is one of the most complex aspects of human experience. Studying the mechanisms involved in transitions and in different levels of consciousness is one of the greatest challenges of neuroscience. In this study ...
  • Dancing epilepsy: A stereo encephalography case report 
    Cámpora, Nuria; Nasimbera, Alejandro; Daza, Anilu; Giagante, Brenda; Oddo, Silvia; Kochen, Silvia (2024-02)
    Ictal semiology is essential to identify the epileptogenic zone (EZ), especially in drug-resistant focal epilepsy (DRE), as its accurate identification determines the surgical prognosis. Dancing is highly unusual ictal ...
  • Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts 
    Romo, Ana; Rodríguez, Tania Melina; Yu, Guo; Dewey, Ricardo Alfredo (2024-01)
    The TGF signaling pathway is a key regulator of cancer progression. In this work, we report for the first time the antitumor activity of TβRII-SE/Fc, a novel peptibody whose targeting domain is comprised ...
  • Evaluation of the osmoprotective and bioprotective effect of trehalose 3% 
    Sendra, Victor; Berra, Alejandro; Michelini, Flavia; Guerbi, Maria Ximena; Rodriguez, Giselle; del Papa, Melina Sol; Passerini, María Silvia (2023-12)
    Purpose: The purpose of this study was to study the osmoprotective and bioprotective effect of trehalose 3% + carboxymethylcellulose (CMC) 0.5% during desiccation conditions. Materials and Methods: Normal human ...
  • Indications for Intracerebral Recording in Candidates for Epilepsy Surgery 
    Oddo, Silvia; Giagante, Brenda; Kochen, Silvia (Springer, 2023-08-30)
    Epilepsy surgery depends on accurate preoperative localization of the epileptogenic zone (EZ). Then, presurgical evaluation is necessary to obtain the most accurate information from clinical, anatomic, and neurophysiologic ...
  • Vasopressin Analog [V(4)Q(5)]dDAVP Exerts Cooperative Anticancer Effects in Combination With Low-Dose 5-Fluorouracil on Aggressive Colorectal Cancer Models 
    Sobol, Natasha T; Solerno, Luisina; Llavona, Candela; Alonso, Daniel F; Garona, Juan (2023-12)
    Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Despite being an essential component of systemic chemotherapy for advanced CRC, 5-fluorouracil (5-FU) clinical use has ...
  • La vacuna de ARNm para el tratamiento del cáncer de páncreas llegó para quedarse 
    Chuluyan, Eduardo; Davio, Carlos; Dusetti, Nelson; Fraunhoffer, Nicolás; Garcia, María Noé; Garona, Juan; González, Betina; Gottardo, Florencia; Grasso, Daniel; Iovanna, Juan; Kohan, Gustavo; Lada, Paul Eduardo; Mazza, Oscar; Monte, Martín; Papademetrio, Daniela; Pasqualini, María Eugenia; Sahores, Ana; Santofimia, Patricia; Yaneff, Agustín (2023-08)
    El adenocarcinoma ductal pancreático (PDAC) es una enfermedad letal, destacada por la altísima semejanza entre su incidencia y mor- talidad1, 2. La supervivencia a 5 años de los pa- cientes con PDAC sigue siendo tan baja ...
  • Cu(II)-acylhydrazone complex, a potent and selective antitumor agent against human osteosarcoma: Mechanism of action studies over in vitro and in vivo models 
    Balsa, Lucia M; Solernó, Luisina; Rodriguez, Maria R; Parajón-Costa, Beatriz S; Gonzalez-Baró, Ana C; Alonso, Daniel; Garona, Juan; León, Ignacio (2023-10-01)
    Osteosarcoma (OS) is a frequent bone cancer, affecting largely children and young adults. Cisplatin (CDDP) has been efficacious in the treatment of different cancer such us OS but the development of ...
  • In Silico and In Vitro Evaluation of Bevacizumab Biosimilar MB02 as an Antitumor Agent in Canine Mammary Carcinoma 
    Cardama, Georgina A; Bucci, Paula L; Lemos, Jesús S; Llavona, Candela; Benavente, Micaela A; Hellmén, Eva; Fara, María Laura; Medrano, Eduardo; Spitzer, Eduardo; Demarco, Ignacio A; Sabella, Patricia; Garona, Juan; Alonso, Daniel F (2023-08-03)
    Canine mammary carcinomas (CMC) are associated with major aggressive clinical behavior and high mortality. The current standard of care is based on surgical resection, without an established effective ...
  • Estudio exploratorio de eficacia de ivermectina combinada a α- PD-1 en cáncer colorrectal resistente a quimioinmunoterapia 
    Llavona, Candela; Solernó, Luisina; González Morán, Florencia; Ledesma, Martín Manuel; Martínez, Giselle; Segatori, Valeria; Alonso, Daniel; Garona, Juan (2023-06-25)
    [RESUMEN]. Las terapias inmunológicas con inhibidores de checkpoints (ICIs) han revolucionado el abordaje del cáncer colorrectal (CCR), pero su efectividad se restringe a tumores inmunorreactivos con deficiencia en la ...
  • NORHA: A NORmal Hippocampal Asymmetry Deviation Index Based on One-Class Novelty Detection and 3D Shape Features 
    Deangeli, Duilio; Iarussi, Francisco; Külsgaard, Hernán; Braggio, Delfina; Princich, Juan Pablo; Bendersky, Mariana; Iarussi, Emmanuel; Larrabide, Ignacio; Orlando, José Ignacio (2023-06-29)
    Radiologists routinely analyze hippocampal asymmetries in magnetic resonance (MR) images as a biomarker for neurodegenerative conditions like epilepsy and Alzheimer's Disease. However, current clinical tools rely on either ...
  • Recomendaciones de manejo de los anticoagulantes orales directos (doacs) anti xa y anti iia 
    Ceresetto, José M.; Tajer, Carlos; Duboscq, Cristina; Bottaro, Federico; Casais, Patricia; Korin, Jorge; Fondevila, Carlos; Giumelli, Carla; Scazziota, Alejandra; Rossi, Andrea; Botto, Fernando; Ariscancela, Maria Ester; Martinuzzo, Marta; Zaidel, Ezequiel; Maurice, Mario Fitz; Bahit, Cecilia; Vazquez, Fernando; Molnar, Soledad; Saizberg, Simón; Aranguren, Pedro Negri; Rosa, Claudio; Fedele, José Luis; Comignani, Pablo; Pombo, Gonzalo; Raña, Pablo; Adamczuk, Yolanda; Adrián Charask; Martí, Alejandra; Charask, Adrián; Penchasky, Diana; Riveros, Dardo; Mariani, Javier; Puente, Dolores; Celebrin, Lucia; Bosio, Martín; Brodsky, Andrés; Lucero, Analía Sanchez; Costa, Yanina Castillo; Hirschson, Alfredo; Arbesú, Guillermo; Viñuales, Susana; Kazelian, Lucía; Maneyro, Alberto; Gutierrez, Victoria; Rios, Miguel Castro; Gagliardi, Juan; Lescano, Adrián; Repetto, Fernanda (2022-03-01)
    Los anticoagulantes orales directos han surgido como una de las herramientas que ha cambiado el manejo de la enfermedad trombótica en los últimos 15 años. Sus ventajas, desde el punto de vista de la facilidad de uso y menor ...
  • Performance of pre-transplant criteria in prediction of hepatocellular carcinoma progression and waitlist dropout 
    Piñero, Federico; Thompson, Marcos; Boin, Ilka; Chagas, Aline; Quiñonez, Emilio; Bermúdez, Carla; Vilatobá, Mario; Santos, Luisa; Anders, Margarita; Duque, Sergio Hoyos; Lima, Agnaldo Soares; Menendez, Josemaría; Padilla, Martín; Poniachik, Jaime; Zapata, Rodrigo; Maraschio, Martín; Menéndez, Ricardo Chong; Muñoz, Linda; Arufe, Diego; Figueroa, Rodrigo; Perales, Simone R.; Maccali, Claudia; Sandoval, Rodrigo Vergara; McCormack, Lucas; Varón, Adriana; Marciano, Sebastián; Mattera, Juan; Carrilho, Flair; Silva, Marcelo (2022-02-25)
    Background & aim: Liver transplantation (LT) selection models for hepatocellular carcinoma (HCC) have not been proposed to predict waitlist dropout because of tumour progression. The aim of this study was to compare the ...
  • Microsurgical anatomy and the importance of the petrosal process of the sphenoid bone in endonasal surgery 
    Gonzalez, Ayoze Doniz; Vigo, Vera; Nunez, Maximiliano Alberto; Xu, Yuanzhi; Mohyeldin, Ahmed; Aaron A. Cohen, Gadol; Juan C. Fernandez, Miranda (2022-03-11)
    The petrosal process of the sphenoid bone (PPsb) is a relevant skull base osseous prominence present bilaterally that can be used as a key surgical landmark, especially for identifying the abducens nerve. The authors ...
  • Valor pronóstico del índice de shock en el infarto de miocardio. Datos del registro argentino de infarto con elevación del segmento st (argen iam-st) 
    Costa, Yanina Castillo; Frontera, Esteban; Mauro, Víctor; Imperio, Heraldo D'; Charask, Adrián; Macin, Stella M; Perna, Eduardo R; Zapata, Gerardo; Perea, Joaquin; Marturano, María Pía; Gagliardi, Juan; Tajer, Carlos (2021-08-09)
    El índice de shock (IS) se obtiene mediante un cálculo simple del cociente entre la frecuencia cardíaca (FC) y la tensión arterial sistólica (PAS) (IS: FC/TAS) y el índice de shock ajustado por edad (ISA) multiplicando el ...